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Enzyme Catalyzed Reactions and their Kinetics ( forår 2008 - 5 ECTS )

Rammer for udbud

  • Uddannelsessprog: (se under Undervisnings- og arbejdsform)
  • Niveau: Graduate course
  • Semester/kvarter: 3rd quarter
  • Timer per uge:
  • Deltagerbegrænsning: No limit.
  • Undervisningssted: Århus
  • Hovedområde: Det Naturvidenskabelige Fakultet
  • Udbud ID: 10503

Formål

At the moment no Danish version - please see the English version.

Indhold

Aims

This course is expected to give the student an insight into the principles and the applications of common measurement and evaluation methods in enzyme catalyzed reactions.

 

Contents

Principles of enzyme catalysis. This includes transition state theory, principles of catalysis, basic equations of enzyme kinetics, steady state and pre-steady state kinetics, irreversible and reversible enzyme inhibition, enzymatic rate constants, rate determining processes, practical methods for kinetics and equilibria, plotting kinetic data, determination of intermediates in enzymatic reactions, use of binding energy in catalysis, enzyme specificity, editing or proofreading mechanism and the cost of accuracy.

Faglige forudsætninger

Bachelor courses in biochemistry (corresponding to "Almen biokemi", "Fysisk biokemi" and "Videregående biokemi")

Underviser

Name: Nes'e Bilgin

Address: Department of Molecular Biology, Science Park Division, 1.2.11   (Building 1, Floor 2 room 11)

Gustov Wieds Vej 10C, DK-8000 Aarhus C

Phone No: +45 29318669

E-mail: bilginne@boun.edu.tr

Undervisnings- og arbejdsform

Teaching material and spoken language: English

Litteratur

Teaching materials/Text-books

Structure and Mechanism in Protein Science. A Guide to Enzyme Catalysis and Protein Folding.

Author: Alan Fersht.

W.H. Freeman and Company New york (1999)

ISBN 0-7167-3268-8

 

Supplementary material:

Biochemistry, 6 th edition (2006)

Authors: J.M. Berg, J. L. Tymoczko and L. Stryer

W.H. Freeman and Company

ISBN: 0-7167-8724-5

Bedømmelse

  • Skriftlig, bedømt efter 7-skala med intern censur
    • 5 xxxxx
  • Two-hour written examination without aids 50%
  • Participation and performance in the problem sessions: 50% (based on homeworks   paper discussions, quizes)
  • Evaluated on basis of the Danish 7-points scale
  • Internal examiner